TRPV 1 ( transient receptor potential cation channel , subfamily V , member 1 )
نویسندگان
چکیده
DNA/RNA Description TRPV1 gene consists of 17 exons and 17 introns including a coding region and a 5' and a 3' non-coding region. Transcription There are four transcript variants encoding the same protein, but with different segments in the 5' UTR (var.1, var.2, var.3, var.4) and one alternative splice variant lacking exon 7 (TRPV1b). TRPV1 gene transcription was demonstrated in different cells and tissues, but no data are available on TRPV1 variant expression profiles.
منابع مشابه
Vanilloid transient receptor potential cation channels: an overview.
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-...
متن کاملPharmacology of vanilloid transient receptor potential cation channels.
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ("Mucolipin"), and TRPA ("Ankyrin"). The TRPV subfamily (vanilloid receptors) comprises channels critically involved in nociception and thermosensing (...
متن کاملExpression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes
Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective cation channels whereas TRPV5 and TRPV6 show high selectivity for calcium over other cations. In this study we investigated the effect of time in cu...
متن کاملHdud, Ismail M. and El-Shafei, Abdelrafea A. and Loughna, Paul and Barrett-Jolley, Richard and Mobasheri, Ali (2012) Expression of transient receptor potential vanilloid (TRPV) channels in different passages
Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective cation channels whereas TRPV5 and TRPV6 show high selectivity for calcium over other cations. In this study we investigated the effect of time in cu...
متن کاملHomo- and heteromeric assembly of TRPV channel subunits.
The vanilloid receptor-related TRP channels (TRPV1-6) mediate thermosensation, pain perception and epithelial Ca(2+) entry. As the specificity of TRPV channel heteromerization and determinants governing the assembly of TRPV subunits were largely elusive, we investigated the TRPV homo- and heteromultimerization. To analyze the assembly of TRPV subunits in living cells, we generated fluorescent f...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology TRPV 2 ( transient receptor potential cation channel , subfamily V , member 2 )
Other names: VRL, VRL-1, VRL1 HGNC (Hugo): TRPV2 Location: 17p11.2 Local order: Colocolizes upstream with UBB (ubiquitin B) and FTLP12 (ferritin, light polypeptide pseudogene 12), and downstream with C17orf76-AS1 (C17orf76 antisense RNA 1) (non-protein coding). DNA/RNA Description TRPV2 gene consists of 15 exons and 14 introns spanning 1 to 21462 bp of DNA from 17p11.2 and includes a 5'-/3'non-...
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